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Assessing Bacterial Invasion of Cardiac Cells in Culture and Heart Colonization in Infected Mice Using Listeria monocytogenes
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Molecular evidence of Listeria monocytogenes infection relapse in a severe case of endocarditis

Giulia Ciceri1, Maria Gori2, Silvia Bianchi1

  • 1Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.

JMM Case Reports
|November 9, 2017
PubMed

Insights

Recurrent Listeria monocytogenes infection causing severe endocarditis is rare. Molecular subtyping confirmed reinfection, aiding clinical diagnosis and highlighting the importance of advanced microbial detection methods.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Cardiology

Background:

  • Endocarditis is a serious complication of Listeria monocytogenes bacteremia, associated with high mortality rates.
  • Recurrent Listeria monocytogenes infections are exceptionally rare, posing diagnostic challenges.

Observation:

  • A 66-year-old patient with an aortic valve prosthesis developed severe endocarditis due to recurrent Listeria monocytogenes infection.
  • The recurrence was definitively confirmed using molecular subtyping techniques, including pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST).

Findings:

  • Molecular subtyping provides robust evidence for microbial reinfection in recurrent cases.
  • Accurate identification of reinfection is crucial for effective clinical management of complex infectious diseases.

Implications:

  • This case underscores the utility of molecular subtyping in diagnosing microbial reinfections.
  • Advanced typing methods are essential for supporting clinical diagnosis and improving patient outcomes in rare infectious disease relapses.
Keywords:
Listeria monocytogenesendocarditisinvasive listeriosismolecular subtypingrelapsesurveillance

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