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Updated: Feb 19, 2026

Efficient Method for Imaging Murine Lungs that Preserves Spatial Dynamics of Fungal Spores in the Airways
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Spread through air spaces (STAS): a comprehensive update.

Arne Warth1,2

  • 1Institute of Pathology, Heidelberg University, Heidelberg, Germany.

Translational Lung Cancer Research
|November 9, 2017
PubMed
Summary
This summary is machine-generated.

Spread through air spaces (STAS) is a key factor in lung adenocarcinoma, impacting patient prognosis and linked to specific characteristics. This review covers recent advancements concerning STAS in lung cancer.

Keywords:
Spread through air spaces (STAS)lung cancermetastasisprognosisrecurrence

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Area of Science:

  • Pulmonology
  • Oncology
  • Pathology

Background:

  • The 2015 World Health Organization (WHO) classification introduced Spread Through Air Spaces (STAS) for pulmonary adenocarcinomas (ADC).
  • Emerging data highlight STAS as a significant prognostic factor in lung cancer.
  • STAS is associated with distinct clinicopathological features.

Purpose of the Study:

  • To provide a comprehensive overview of recent developments regarding Spread Through Air Spaces (STAS) in lung adenocarcinoma.
  • To synthesize current knowledge on the prognostic impact and associated characteristics of STAS.
  • To update understanding of STAS in the context of lung cancer classification.

Main Methods:

  • Literature review of recent studies on STAS in pulmonary adenocarcinomas.
  • Analysis of data linking STAS to prognostic outcomes.
  • Examination of clinicopathological features associated with STAS.

Main Results:

  • STAS is a critical prognostic indicator in lung adenocarcinoma.
  • Specific clinicopathological features are consistently associated with the presence of STAS.
  • Recent research has expanded the understanding of STAS's role and implications.

Conclusions:

  • STAS is an important pathological feature with significant prognostic value in lung adenocarcinoma.
  • Further research continues to elucidate the clinical relevance of STAS.
  • Awareness and accurate assessment of STAS are crucial for lung cancer management.