Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

835
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
835
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

357
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
357
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

1.2K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
1.2K
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

1.0K
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.0K
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

370
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
370
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

522
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
522

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measured and Estimated Glomerular Filtration Rates and Risk of Adverse Health Outcomes.

JAMA·2026
Same author

Glomerular Filtration Markers: Current and Emerging Insights.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Medications Influencing Serum Cystatin C Independent of Measured GFR.

Journal of the American Society of Nephrology : JASN·2026
Same author

Determining baseline serum creatinine in harmonized criteria for kidney disease: unfinished business.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Population-based estimated Glomerular Filtration Rate distributions and associated health outcomes provide opportunities for early identification of and primary prevention of chronic kidney disease.

Kidney international·2026
Same author

Metabolomic Changes After Bariatric Surgery Adjusted for Glomerular Filtration Rate Suggest Mechanisms of Kidney Protection.

Obesity (Silver Spring, Md.)·2025
Same journal

Correction to I.M. Matters News: Sleep medicine for seniors.

Annals of internal medicine·2026
Same journal

Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone : A Target Trial Emulation.

Annals of internal medicine·2026
Same journal

Leveraging Real-World Evidence to Inform Regulatory, Clinical, and Coverage Decisions Related to Glucagon-Like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Methodological Approaches to Real-World Evidence Generation for Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Weekly and Biweekly Treatment With Bofanglutide Versus Semaglutide in Chinese Patients With Type 2 Diabetes : A Phase 2b Randomized Clinical Trial.

Annals of internal medicine·2026
Same journal

Grappling with GLP-1 prescribing.

Annals of internal medicine·2026
See all related articles

Related Experiment Video

Updated: Feb 19, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.9K

Acute Kidney Injury.

Andrew S Levey1, Matthew T James1

  • 1From Tufts Medical Center, Boston, Massachusetts, and the University of Calgary, Calgary, Alberta.

Annals of Internal Medicine
|November 9, 2017
PubMed
Summary
This summary is machine-generated.

Acute kidney injury (AKI) affects 20% of hospitalized patients, causing serious complications. Management involves treating the cause and complications, with kidney replacement therapy reserved for severe cases.

More Related Videos

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

2.5K
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

9.3K

Related Experiment Videos

Last Updated: Feb 19, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.9K
Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice
02:45

Bilateral Renal Ischemia-Reperfusion Model for Acute Kidney Injury in Mice

Published on: February 2, 2024

2.5K
Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
07:58

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

9.3K

Area of Science:

  • Nephrology
  • Internal Medicine
  • Critical Care Medicine

Background:

  • Acute kidney injury (AKI) is a common and serious condition in hospitalized patients.
  • It is characterized by a rapid decline in kidney function, indicated by increased serum creatinine or reduced urine output.
  • AKI affects approximately 20% of individuals admitted to hospitals.

Purpose of the Study:

  • To provide a comprehensive overview of acute kidney injury.
  • To outline the classification, complications, and management strategies for AKI.
  • To highlight the significant mortality associated with severe AKI requiring kidney replacement therapy.

Main Methods:

  • The abstract synthesizes current knowledge on AKI.
  • It describes the clinical presentation and diagnostic indicators of AKI.
  • It reviews established management principles and therapeutic interventions for AKI.

Main Results:

  • AKI presents heterogeneously with varying stages and causes.
  • Common complications include fluid overload, electrolyte imbalances, uremia, and drug toxicity.
  • Kidney replacement therapy is indicated for refractory complications, but carries a high mortality risk.

Conclusions:

  • Effective management of AKI requires addressing both the underlying cause and its complications.
  • Despite medical advancements, severe AKI necessitating kidney replacement therapy has a persistent high mortality rate of around 50%.