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Introducing multiple bio-functional groups on the poly(ether sulfone) membrane substrate to fabricate an effective
Lingren Wang1, Min He, Tao Gong
1Jiangsu Provincial Key Laboratory for Interventional Medical Devices. Huaiyin Institute of Technology, Huaian 223003, China.
Biomaterials Science
|November 9, 2017
Summary
Introducing functional groups onto poly(ether sulfone) (PES) membranes improves blood compatibility. Modified membranes show reduced platelet activation and enhanced endothelial cell proliferation, indicating potential for blood-contacting applications.
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Hemocompatibility Research
Background:
- Functional groups on biomaterial surfaces are critical for blood compatibility.
- Poly(ether sulfone) (PES) membranes require surface modification for improved antithrombotic properties.
Purpose of the Study:
- To develop an antithrombotic bio-interface on PES membranes.
- To introduce sodium carboxylic, sodium sulfonic, and amino groups onto PES surfaces.
Main Methods:
- Synthesized PES with carboxylic (CPES) and sodium sulfonic/amino (SNPES) groups.
- Blended CPES with PES to introduce carboxylic groups.
- Grafted SNPES onto CPES/PES membranes via amino-carboxyl coupling.
Main Results:
- Modified membranes exhibited inhibited platelet adhesion and activation.
- Prolonged clotting times and suppressed complement activation were observed.
- Enhanced endothelial cell proliferation demonstrated improved cytocompatibility.
Conclusions:
- Surface functionalization of PES membranes significantly enhances hemocompatibility.
- The modified membranes show promise for blood-contacting applications like hemodialysis.
- Synergistic effects of functional groups promote endothelialization and biomaterial performance.
