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Extreme pyrexia during bretylium administration
P E Perlman1, W G Adams, N A Ridgeway
1Quillen-Dishner College of Medicine, East Tennessee State University, Kingsport.
Postgraduate Medicine
|January 1, 1989
Summary
Extreme pyrexia, a dangerous rise in body temperature, was observed during bretylium infusion for ventricular fibrillation. The patient
Area of Science:
- Cardiology
- Clinical Pharmacology
Background:
- Refractory ventricular fibrillation necessitates advanced treatment strategies.
- High-grade fevers are uncommon but serious adverse events in critical care settings.
Observation:
- A patient receiving intravenous bretylium for refractory ventricular fibrillation developed extreme pyrexia.
- Body temperature reached 42.3 degrees C (108.2 degrees F) during the bretylium infusion.
Findings:
- Bretylium administration was directly correlated with the onset of extreme pyrexia.
- The patient's temperature normalized within four hours after discontinuing the bretylium infusion.
Implications:
- This case suggests bretylium tosylate may induce extreme pyrexia.
- Clinicians should monitor for hyperthermia during bretylium administration.
- Further investigation into the mechanism of bretylium-induced pyrexia is warranted.