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Related Experiment Videos

Extreme pyrexia during bretylium administration.

P E Perlman1, W G Adams, N A Ridgeway

  • 1Quillen-Dishner College of Medicine, East Tennessee State University, Kingsport.

Postgraduate Medicine
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

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Extreme pyrexia, a dangerous rise in body temperature, was observed during bretylium infusion for ventricular fibrillation. The patient

Area of Science:

  • Cardiology
  • Clinical Pharmacology

Background:

  • Refractory ventricular fibrillation necessitates advanced treatment strategies.
  • High-grade fevers are uncommon but serious adverse events in critical care settings.

Observation:

  • A patient receiving intravenous bretylium for refractory ventricular fibrillation developed extreme pyrexia.
  • Body temperature reached 42.3 degrees C (108.2 degrees F) during the bretylium infusion.

Findings:

  • Bretylium administration was directly correlated with the onset of extreme pyrexia.
  • The patient's temperature normalized within four hours after discontinuing the bretylium infusion.

Implications:

  • This case suggests bretylium tosylate may induce extreme pyrexia.

Related Experiment Videos

  • Clinicians should monitor for hyperthermia during bretylium administration.
  • Further investigation into the mechanism of bretylium-induced pyrexia is warranted.