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Updated: Feb 19, 2026
07:42
An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
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Update on management of invasive candidiasis
F J Candel1, C Pazos Pacheco, I Ruiz-Camps
1Dr Francisco Javier Candel González, Department of Clinical Microbiology and Infectious Diseases. Hospital Clínico San Carlos. IDISSC. Universidad Complutense. Avda Profesor Martín Lagos s/n, 28040. Madrid, Spain. fj.candel@gmail.com.
Summary
Early diagnosis of invasive candidiasis in critically ill and cancer patients is crucial. This review highlights culture-independent tests and serological markers to improve antifungal therapy and patient outcomes.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Critical Care Medicine
Background:
- Invasive candidiasis incidence is rising in critically ill and hematologic oncology patients.
- Poor outcomes necessitate improved diagnostic and therapeutic strategies.
- Early detection and treatment significantly impact prognosis.
Purpose of the Study:
- To review current culture-independent diagnostic methods for invasive candidiasis.
- To update therapeutic algorithms based on evidence and guidelines.
- To explore the role of clinical prediction scores and fungal serological markers.
Main Methods:
- Review of current literature on culture-independent microbiological tests.
- Analysis of epidemiological data and risk factors for invasive candidiasis.
- Synthesis of international guidelines for therapeutic approaches.
Main Results:
- Culture-independent tests offer promising diagnostic avenues.
- Combining clinical scores with serological markers can optimize antifungal therapy.
- Updated algorithms provide a framework for managing invasive candidiasis.
Conclusions:
- Early diagnosis and targeted antifungal therapy are key for better patient prognosis.
- Non-culture-based methods and biomarker combinations are vital for timely intervention.
- Evidence-based guidelines are essential for optimizing treatment in high-risk populations.
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