Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

HACC-TNF-α-VLP Nanoparticles Facilitate HSP90-Dependent Antigen Cross-Presentation to Enhance CD8⁺ T Cell and Mucosal Immunity Against Foot-and-Mouth Disease.

International journal of nanomedicine·2026

Same author

Spider-Leg-Inspired Structural Design and Bézier Foot Trajectory Planning for Stable Walking of a Hexapod Robot.

Biomimetics (Basel, Switzerland)·2026

Same author

Magnetic medical microrobots with memory-capable genetic circuits.

Science advances·2026

Same author

Manipulation therapy alleviates neuropathic pain <i>via</i> the SOCS1 m<sup>6</sup>A epigenetic loop.

The Korean journal of pain·2026

Same author

Sodium Danshensu promotes diabetic wound healing by targeting the EGFR-mediated PI3K-AKT pathway: a combined network pharmacology, machine learning, and <i>in vitro</i> approach.

RSC advances·2026

Same author

Knockdown of miR-21-5P targets and regulates PDCD4-induced apoptosis in ovarian granulosa cells and ameliorates in sulin resistance in polycystic ovary syndrom.

PloS one·2026

Search research articles

Related Experiment Video

Updated: Feb 19, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

Predicting pathogenic genes for primary myelofibrosis based on a system‑network approach.

Shu-Cai Xu¹, Peng Ning²

¹Department of Oncology and Hematology, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan, Hubei 430015, P.R. China.

Molecular Medicine Reports

|November 9, 2017

Summary

This study identifies 10 candidate pathogenic genes for primary myelofibrosis (PMF) by integrating gene expression and protein-protein interaction networks. These findings offer new insights into PMF pathogenesis and potential therapeutic targets.

More Related Videos

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Related Experiment Videos

Last Updated: Feb 19, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

Area of Science:

Genetics
Bioinformatics
Systems Biology

Background:

Primary myelofibrosis (PMF) is a serious myeloproliferative neoplasm.
Understanding the genetic basis of PMF is crucial for developing effective treatments.

Purpose of the Study:

To predict novel pathogenic genes for PMF using a systems-network approach.
To identify key biological pathways involved in PMF pathogenesis.

Main Methods:

Combined protein-protein interaction (PPI) networks with gene expression data and known pathogenic genes.
Identified differentially expressed genes (DEGs) and seed genes in PMF.
Constructed a pathogenic network and mined pathogenic modules using cluster analysis.

Main Results:

Identified 845 DEGs and 45 seed genes in PMF.
Constructed a pathogenic network with 103 nodes and 265 interactions.
Discovered 4 pathogenic modules, identifying 10 candidate pathogenic genes, including EP300, RARA, VWF, and RAF1.

Conclusions:

The study successfully predicted candidate pathogenic genes and signaling pathways in PMF using a systems-network approach.
These findings provide a foundation for future experimental validation and may guide PMF therapeutic strategies.