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WWC3 Inhibits Glioma Cell Proliferation Through Suppressing the Wnt/β-Catenin Signaling Pathway

Yanni Wang1, Man Jiang2, Yongshan Yao3

  • 11 Department of Pediatrics, The First College of Clinical Medical Science, China Three Gorges University , Yi Chang City, China .

DNA and Cell Biology
|November 9, 2017
PubMed

Insights

WW and C2 domain-containing protein 3 (WWC3) is downregulated in glioma, inhibiting tumor growth. WWC3 suppresses beta-catenin signaling, suggesting it as a potential therapeutic target for glioma treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • WW and C2 domain-containing protein 3 (WWC3) is a scaffolding protein involved in cell signaling.
  • The role of WWC3 in glioma tumorigenesis is largely unexplored.
  • Glioma is a primary brain tumor with significant unmet clinical needs.

Purpose of the Study:

  • To investigate the expression and function of WWC3 in glioma.
  • To elucidate the molecular mechanism underlying WWC3's role in glioma.
  • To evaluate WWC3 as a potential therapeutic target for glioma.

Main Methods:

  • Analysis of WWC3 expression in glioma tissues and cell lines.
  • In vitro experiments assessing the effects of WWC3 overexpression and depletion on glioma cell behavior (proliferation, migration, invasion).
  • Investigation of WWC3's interaction with the beta-catenin/Wnt signaling pathway and T cell factor 4 (TCF4).

Main Results:

  • WWC3 expression was significantly downregulated in glioma tissues and cell lines.
  • Overexpression of WWC3 inhibited glioma cell proliferation, migration, and invasion.
  • Depletion of WWC3 promoted glioma cell proliferation.
  • WWC3 suppressed beta-catenin/Wnt signaling activity by interacting with TCF4, potentially inhibiting beta-catenin transcriptional activation.

Conclusions:

  • WWC3 acts as a tumor suppressor in glioma.
  • The aberrant downregulation of WWC3 and its interaction with TCF4 contribute to glioma progression.
  • WWC3 represents a promising novel therapeutic target for clinical intervention in glioma.
Keywords:
TCF4WWC3Wnt/β-catenincell proliferationglioma

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