A review of current and developing fixed-dose LABA/LAMA combinations for treating COPD
1a Pulmonary, Critical Care, Allergy and Sleep Medicine , Medical University of South Carolina , Charleston , SC , USA.
Expert Opinion on Pharmacotherapy
|November 9, 2017
Summary
Long-acting bronchodilator combinations, including long-acting beta2-agonists (LABA) and long-acting muscarinic antagonists (LAMA), are key for managing chronic obstructive pulmonary disease (COPD). These combinations improve adherence and are preferred for preventing COPD exacerbations.
Area of Science:
- Pulmonology
- Pharmacology
Background:
- Current Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines recommend long-acting beta2-agonists (LABA) and long-acting muscarinic antagonists (LAMA) combinations for specific COPD patient groups (B, C, D).
- Significant interest exists in developing LABA/LAMA combinations for the maintenance therapy of chronic stable COPD.
Purpose of the Study:
- To review the current clinical use and evolving landscape of LABA/LAMA combinations in COPD management.
- To highlight the benefits of combining bronchodilator classes in a single inhaler for improved patient adherence.
Main Methods:
- Review of pivotal clinical trials and updated GOLD guidelines.
- Analysis of the role of LABA/LAMA combinations in COPD exacerbation prevention.
Main Results:
- Numerous LABA/LAMA combinations have been successfully approved via clinical trials.
- These combinations are increasingly recognized as a preferred treatment for preventing COPD exacerbations.
Conclusions:
- LABA/LAMA combinations are clinically important and will see continued use in COPD management.
- Future COPD treatment should adopt a personalized approach, considering individual patient phenotypes.
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