Ventricular depolarisation vectors in exercise induced myocardial ischaemia
Cameruddin W Vellani1, Mohammad Yusuf2, Sadia Mahmud3
1Section of Cardiology, Department of Medicine, The Aga Khan University Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan. camer.vellani@aku.edu.
Scientific Reports
|November 9, 2017
Summary
This study presents a new method to detect myocardial ischaemia by analyzing electrical vector changes during exercise. This approach could lead to a portable, low-cost tool for diagnosing coronary artery disease.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Diagnostics
Background:
- Ischaemia impairs myocardial electrical activity and conduction.
- Altered electrical forces due to ischaemia are reflected in electrocardiographic signals.
- Current diagnostic methods for coronary artery disease can be invasive or costly.
Purpose of the Study:
- To develop a non-invasive method for assessing myocardial ischaemia.
- To investigate changes in electrical vectors during exercise as an indicator of ischaemia.
- To explore the potential for a portable, low-cost diagnostic tool.
Main Methods:
- Utilized a bipolar orthogonal lead system to derive electrical vectors in three planes.
- Measured changes in the magnitude and direction of resultant electrical forces during exercise.
- Analyzed vector changes in patients with varying effort tolerance and signs of ischaemia.
Main Results:
- A significant reduction in vector magnitude during exercise was observed in patients with impaired effort tolerance and ischaemia.
- The method successfully differentiated between patient groups based on exercise-induced vector changes.
- Demonstrated the potential of exercise-induced depolarisation vector spectrum analysis.
Conclusions:
- Measurement of exercise-induced changes in depolarisation vectors offers a promising non-invasive assessment of myocardial ischaemia.
- This technique could form the basis of a portable, low-cost tool for investigating coronary artery disease symptoms.
- Further development could enhance early detection and management of ischaemic heart disease.
More Related Videos
09:23Confirmation of Myocardial Ischemia and Reperfusion Injury in Mice Using Surface Pad Electrocardiography
Published on: November 24, 2016
13.9K
09:26Optical Mapping of Intra-Sarcoplasmic Reticulum Ca2+ and Transmembrane Potential in the Langendorff-perfused Rabbit Heart
Published on: September 10, 2015
9.8K
Related Concept Videos
01:30Cardiac Action Potential
7.2K
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
7.2K
01:25Correlation between ECG and Cardiac Cycle
13.1K
The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
13.1K
01:19Electrophysiology of Normal Cardiac Rhythm
9.8K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
9.8K
01:29Electrocardiogram
6.7K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
6.7K
01:28Mechanism of Cardiac Arrhythmias
2.4K
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
2.4K
01:28Electrocardiogram Fundamentals
1.6K
Introduction
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
1.6K