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Chronic meningoencephalitis caused by Echo virus 6 in a patient with common variable immunodeficiency : Successful

Igor Radanović1, Deni Rkman1, Paulo Zekan1

  • 1School of Medicine, University of Zagreb, Šalata 3b, Zagreb, Croatia.

Wiener Klinische Wochenschrift
|November 9, 2017
PubMed

Insights

Pleconaril effectively treated chronic enteroviral meningoencephalitis in an immunocompromised patient. This case highlights pleconaril

Area of Science:

  • Virology
  • Immunology
  • Neurology

Background:

  • Chronic enteroviral meningoencephalitis is a severe complication, particularly in patients with agammaglobulinemia.
  • Enteroviruses, commonly echoviruses, can cause serious illness, especially in immunocompromised individuals.
  • No specific antiviral treatment for enteroviral infections is currently established.

Observation:

  • A 42-year-old male with common variable immunodeficiency presented with severe chronic meningoencephalitis.
  • The meningoencephalitis was diagnosed as being caused by Echo virus 6.
  • The patient had a history of recurrent sinopulmonary infections.

Findings:

  • The patient was successfully treated with the antiviral drug pleconaril.
  • Pleconaril demonstrated efficacy in treating this severe enteroviral infection.
  • Enteroviral infections can be life-threatening in immunocompromised hosts.

Implications:

  • This case suggests pleconaril is a viable treatment option for severe enteroviral meningoencephalitis.
  • Further investigation into pleconaril's availability and use in immunocompromised patients is warranted.
  • The findings may encourage the continued availability of pleconaril for rare but severe enteroviral diseases.
Keywords:
CVIDEchovirusesEnterovirusMeningoencephalitisPleconaril

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