Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

31
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
31
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

25
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
25

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insight into the reactivity and antitumoral potential of allyl rhodanine derivatives: Azomethine ylide cycloadditions, molecular docking, and SAR studies.

Bioorganic chemistry·2026
Same author

Cyclodextrin-siderophore conjugates as a Trojan horse strategy for bacterial targeting.

Journal of inorganic biochemistry·2026
Same author

Positively Charged Polymers Based on Cyclodextrins for Trametinib and Selumetinib Delivery in Glioblastoma Cancer.

ChemMedChem·2026
Same author

Light and Alternating Temperatures Release Seed Dormancy in the Invasive Dipsacus fullonum L. Through ROS Homeostasis and ABA Regulation.

Physiologia plantarum·2025
Same author

Functionalizing cryogels with the GPGKLVFF peptide for amyloid-β binding: A comparative study of two synthetic pathways.

International journal of biological macromolecules·2025
Same author

Copper(II) and zinc(II) complexes of dimeric 8-hydroxyquinoline ligands: Synthesis, metal speciation, and biological evaluation.

Journal of inorganic biochemistry·2025

Related Experiment Video

Updated: Feb 19, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.6K

Cyclodextrin polymers as nanocarriers for sorafenib.

Valentina Giglio1, Maurizio Viale2, Vittorio Bertone3

  • 1Dipartimento di Scienze Chimiche, Università degli Studi di Catania, V.le A.Doria 6, 95125, Catania, Italy.

Investigational New Drugs
|November 9, 2017
PubMed
Summary

Cyclodextrin-based polymeric nanoparticles effectively solubilize the cancer drug sorafenib, showing similar anti-tumor effects and reduced toxicity compared to the free drug.

Keywords:
Anticancer drugDrug carriersNanoparticlesSolubilityToxicity

More Related Videos

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.6K
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

10.2K

Related Experiment Videos

Last Updated: Feb 19, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

15.6K
Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.6K
Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
09:47

Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes

Published on: February 19, 2016

10.2K

Area of Science:

  • Nanomedicine
  • Polymer Chemistry
  • Drug Delivery

Background:

  • Cyclodextrin-based polymeric nanoparticles are emerging nanotherapeutics in clinical trials.
  • Poorly water-soluble drugs pose formulation challenges.
  • Sorafenib is a key therapeutic agent with limited solubility.

Purpose of the Study:

  • To evaluate cyclodextrin cross-linked polymers as carriers for sorafenib.
  • To assess the impact of polymer length on drug solubility and delivery.
  • To investigate the in vitro and in vivo performance of polymer/sorafenib complexes.

Main Methods:

  • Synthesis of cyclodextrin cross-linked polymers of varying lengths.
  • Preparation and characterization of sorafenib inclusion complexes.
  • In vitro antiproliferative assays using tumor cells.
  • In vivo toxicity studies in animal models.

Main Results:

  • Both polymer types significantly increased sorafenib solubility.
  • Shorter polymers demonstrated superior solubilizing efficacy.
  • Sorafenib-polymer complexes retained antiproliferative activity against tumor cells.
  • Complexation reduced in vivo tissue toxicity compared to free sorafenib.

Conclusions:

  • Polymeric nanoparticles based on cyclodextrins are effective carriers for sorafenib.
  • This formulation strategy enhances drug solubility and reduces toxicity.
  • Further development of these nanocarriers holds promise for improved cancer therapy.