Related Experiment Video
Updated: Feb 19, 2026
08:39
Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
Published on: May 16, 2022
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CGRP Monoclonal Antibodies for Migraine: Rationale and Progress
Hsiangkuo Yuan1, Clinton G Lauritsen1, Eric A Kaiser2
1Jefferson Headache Center, Thomas Jefferson University, 900 Walnut Street, Suite 200, Philadelphia, PA, 19107, USA.
Summary
Calcitonin gene-related peptide (CGRP) plays a key role in migraine. Blocking CGRP with monoclonal antibodies (mAbs) shows promising clinical efficacy and safety for migraine prevention.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Calcitonin gene-related peptide (CGRP) is a neuropeptide implicated in migraine pathophysiology.
- CGRP is involved in modulating nociception and neurogenic inflammation within the trigeminal system.
Purpose of the Study:
- To review the fundamental role of CGRP in migraine pathogenesis.
- To discuss the clinical efficacy of CGRP function-blocking monoclonal antibodies (mAbs) in migraine management.
Main Methods:
- Review of existing literature on CGRP's role in migraine.
- Analysis of clinical trial data for CGRP-targeting mAbs.
Main Results:
- Functional blockade of CGRP, via receptor antagonists or mAbs, demonstrates clinical efficacy in migraine management.
- Four CGRP function-blocking mAbs are in clinical investigation for migraine prophylaxis, with promising Phase II and III results and favorable safety profiles.
Conclusions:
- CGRP is a validated therapeutic target for migraine.
- CGRP function-blocking mAbs represent a potentially revolutionary approach to migraine prophylaxis.
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