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Updated: Feb 19, 2026

Assessing Cerebral Autoregulation via Oscillatory Lower Body Negative Pressure and Projection Pursuit Regression
Published on: December 10, 2014
Challenges of Cerebral Perfusion Pressure Measurement
Sarah L Livesay1, Molly M McNett, Monica Keller
1Questions or comments about this article may be directed to Sarah L. Livesay, DNP RN ACNP-BC ACNS-BC, at sarah_l_livesay@rush.edu. She is an Associate Professor, Department of Adult and Gerontological Nursing, Rush University College of Nursing, Chicago, IL. Molly M. McNett, PhD RN, is Director, MetroHealth, Cleveland, OH. Monica Keller, BSN RN, is Staff Nurse, UT Southwestern, Dallas, TX. DaiWai M. Olson, PhD RN, is Associate Professor, Department of Neurology, Neurotherapeutics, and Neurological Surgery, UT Southwestern, Dallas, TX.
Abstract:
Monitoring cerebral perfusion pressure (CPP) is recommended by a number of clinical practice guidelines and is a routine function performed by critical care neuroscience nurses. However, several studies highlight theoretical and practice variations in the measurement of CPP regarding the location of the arterial pressure transducer during measurement. Agreement on the technique and process for obtaining valid measurements is lacking. This article identifies the challenges associated with CPP measurement and highlights opportunities for standardizing CPP measurement to improve consistency in care and findings reported in the research literature. The challenges associated with practice variations impact multiple nursing domains, including the environment, patient treatment, and team communication; all ultimately impacting nursing workflow. The practice variation and impact on nursing workflow have significant implications for further research, electronic health record development, and refining monitoring technology.
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