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The involvement of platelet activating factor in ovulation
A O Abisogun1, P Braquet, A Tsafriri
1Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel.
Science (New York, N.Y.)
|January 20, 1989
Summary
Platelet activating factor (PAF) plays a role in ovulation. Blocking PAF with BN52021 inhibited follicle rupture, suggesting PAF as a target for reproductive regulation.
Area of Science:
- Reproductive biology
- Endocrinology
- Inflammation research
Background:
- Ovulation involves inflammation-like processes.
- Platelet activating factor (PAF) is implicated in inflammatory responses.
Purpose of the Study:
- To investigate the role of PAF in ovulation.
- To determine the effect of a PAF-specific antagonist (BN52021) on the ovulatory response in rats.
Main Methods:
- Administration of BN52021 locally in rats stimulated to ovulate with human chorionic gonadotropin (hCG).
- Assessment of follicle rupture, ovarian collagenolysis, and vascular permeability.
- Reversal studies using simultaneous administration of PAF and inhibitors of eicosanoid synthesis.
Main Results:
- BN52021 inhibited follicle rupture and suppressed the hCG-stimulated increase in ovarian collagenolysis and vascular permeability.
- The inhibitory effect of BN52021 on ovulation was reversed by co-administration of PAF.
- PAF partially reversed ovulation blockage induced by eicosanoid synthesis inhibitors.
Conclusions:
- Platelet activating factor (PAF) is involved in the process of ovulation.
- PAF's role in ovulation is linked to arachidonic acid metabolism.
- Modulating PAF action presents a potential strategy for regulating reproduction through ovulation control.