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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Related Experiment Video

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Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
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MEMS devices for drug delivery.

Hyunjoo J Lee1, Nakwon Choi2, Eui-Sung Yoon3

  • 1School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.

Advanced Drug Delivery Reviews
|November 9, 2017
PubMed
Summary

Novel drug delivery systems using microtechnology offer controlled drug release, overcoming limitations of oral and injection methods. These advanced systems target difficult areas like the brain, improving treatment for various conditions.

Keywords:
Blood-brain barrier (BBB) disruptionBrain infusionCapsule endoscopeImplantable drug deliveryMicroneedlesTransdermal drug delivery

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Area of Science:

  • Biotechnology
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Novel drug delivery systems (NDDS) leverage microtechnology for spatiotemporal and dosage control.
  • Current limitations in drug delivery include challenges with oral administration and hypodermic injection for specific drug types and target sites.

Purpose of the Study:

  • To review recent advances in microtechnology-based NDDS.
  • To identify and summarize unresolved challenges in targeted drug delivery to specific anatomical regions.
  • To highlight opportunities for innovation in NDDS.

Main Methods:

  • Literature review of microtechnology-based drug delivery systems.
  • Analysis of design considerations and challenges for delivery to protected areas (brain, posterior eye, GI tract).
  • Summary of recent advancements and remaining problems.

Main Results:

  • Microtechnology enables controlled delivery of insoluble/unstable drugs.
  • Targeted delivery to challenging sites like the brain and posterior eye segment is advancing.
  • Localized delivery and improved patient compliance are key benefits.

Conclusions:

  • Microtechnology-based NDDS show significant promise as alternatives to traditional delivery methods.
  • Integration of microtechnology, biomaterials, and biotechnology is crucial for future innovation.
  • Further research is needed to overcome remaining technological and societal hurdles.