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Unravelling the roles of innate lymphoid cells in cerebral malaria pathogenesis

J Palomo1,2, V F J Quesniaux1, D Togbe1,3

  • 1Laboratory of Experimental and Molecular Immunology and Neurogenetics (INEM), UMR 7355 CNRS, University of Orleans, Orleans-Cedex2, France.

Parasite Immunology
|November 9, 2017
PubMed

Insights

Innate lymphoid cells (ILCs) and non-lymphoid cells play emerging roles in experimental cerebral malaria (ECM) pathogenesis, contributing to central nervous system inflammation and disease outcomes in Plasmodium infections.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Neuroscience

Background:

  • Cerebral malaria (CM) involves severe Plasmodium infection complications.
  • It triggers robust inflammatory responses in the central nervous system (CNS).
  • Lung inflammation and anemia are also associated with CM.

Purpose of the Study:

  • To review the role of the innate immune response in experimental cerebral malaria (ECM).
  • To highlight the emerging roles of innate lymphoid cells (ILCs) in ECM.
  • To discuss the contribution of non-lymphoid cells like neutrophils and platelets.

Main Methods:

  • Focus on experimental cerebral malaria (ECM) models.
  • Review of innate immune cell involvement.
  • Analysis of Plasmodium berghei ANKA infection.

Main Results:

  • T cells are critical for ECM pathogenesis.
  • The role of innate lymphoid cells (ILCs) in ECM is increasingly recognized.
  • Neutrophils and platelets contribute to the host immune response in ECM.

Conclusions:

  • Innate immune cells, including ILCs, neutrophils, and platelets, are crucial in ECM.
  • Understanding these cells offers insights into human cerebral malaria (HCM) pathogenesis.
  • Further research into innate immunity is vital for CM treatment strategies.
Keywords:
PlasmodiumILCNK cellscerebral malariamicrobiota and metabolitesneutrophilsplatelets

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