Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

770
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
770

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Left frontal activity measured by fNIRS during a verbal memory task is modulated by predictability in cognitively healthy older adults.

Neuroimage. Reports·2026
Same author

Automated EEG Classification to Track Levels of Consciousness.

medRxiv : the preprint server for health sciences·2026
Same author

Improved autobiographical memory with central thalamic deep brain stimulation in traumatic brain injury.

Brain communications·2026
Same author

Neurophysiological correlates of delayed recovery of consciousness in a critically ill patient with COVID-19 with repeated cardiac arrest.

British journal of anaesthesia·2026
Same author

Determinants of Delayed Recovery of Consciousness After Analgosedation Discontinuation in the ICU: Insights From Patients With COVID-19 Hypoxemic Respiratory Failure.

Critical care medicine·2026
Same author

40 Hz audiovisual stimulation improves sustained attention and related brain oscillations.

Imaging neuroscience (Cambridge, Mass.)·2026

Related Experiment Video

Updated: Feb 19, 2026

A Rapid Approach to High-Resolution Fluorescence Imaging in Semi-Thick Brain Slices
04:35

A Rapid Approach to High-Resolution Fluorescence Imaging in Semi-Thick Brain Slices

Published on: July 26, 2011

16.9K

Illuminating Neural Circuits: From Molecules to MRI.

Jin Hyung Lee1, Anatol C Kreitzer2, Annabelle C Singer3

  • 1Stanford University, Stanford, California 94305, ljinhy@stanford.edu.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 10, 2017
PubMed
Summary

Understanding neural circuit mechanisms is key to diagnosing and treating neurological diseases. New technologies reveal how circuit dysfunction causes motor and arousal problems, offering hope for novel therapies.

Keywords:
Alzheimer's diseasearousalbasal gangliagamma frequencyofMRIoptogenetics

More Related Videos

Optogenetic Functional MRI
06:06

Optogenetic Functional MRI

Published on: April 19, 2016

15.5K
Multi-Fiber Photometry to Record Neural Activity in Freely-Moving Animals
05:52

Multi-Fiber Photometry to Record Neural Activity in Freely-Moving Animals

Published on: October 20, 2019

38.5K

Related Experiment Videos

Last Updated: Feb 19, 2026

A Rapid Approach to High-Resolution Fluorescence Imaging in Semi-Thick Brain Slices
04:35

A Rapid Approach to High-Resolution Fluorescence Imaging in Semi-Thick Brain Slices

Published on: July 26, 2011

16.9K
Optogenetic Functional MRI
06:06

Optogenetic Functional MRI

Published on: April 19, 2016

15.5K
Multi-Fiber Photometry to Record Neural Activity in Freely-Moving Animals
05:52

Multi-Fiber Photometry to Record Neural Activity in Freely-Moving Animals

Published on: October 20, 2019

38.5K

Area of Science:

  • Neuroscience
  • Neurology
  • Systems Biology

Background:

  • Neurological diseases manifest as symptoms stemming from altered neural circuit function.
  • Quantitative diagnosis and effective treatment necessitate a deep understanding of these circuit mechanisms.
  • Behavioral dysfunction in neurological disorders is directly linked to pathological changes in neural circuits.

Purpose of the Study:

  • To highlight technologies for measuring and manipulating neural activity and circuits.
  • To explore circuit mechanisms underlying specific neurological dysfunctions.
  • To discuss the potential of circuit-based interventions for treating neurological diseases.

Main Methods:

  • Utilized advanced technologies for neural activity and circuit measurement.
  • Employed methods for targeted manipulation of neural circuits.
  • Integrated optogenetic functional magnetic resonance imaging (ofMRI) for large-scale circuit analysis.

Main Results:

  • Discovered specific circuit mechanisms driving pathological motor behavior.
  • Identified neural circuit underpinnings of arousal regulation deficits.
  • Elucidated circuit-based contributions to protein accumulation in neurological conditions.
  • Optogenetic fMRI revealed global circuit mechanisms in neurological disease models.

Conclusions:

  • Understanding neural circuit function is crucial for neurological disease diagnosis and treatment.
  • Technological advancements enable detailed investigation of circuit mechanisms.
  • Circuit manipulation strategies hold promise for developing novel therapeutic interventions for neurological disorders.