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Pediatric Optic Pathway/Hypothalamic Glioma.
Yasuo Aihara1, Kentaro Chiba1, Seiichiro Eguchi1
1Department of Neurosurgery, Tokyo Women's Medical University.
Neurologia Medico-Chirurgica
|November 10, 2017
Summary
Optic pathway/hypothalamic gliomas (OP/HGs) are rare pediatric tumors. Surgical resection offers acceptable outcomes, but chemotherapy remains the gold standard for managing these challenging brain tumors.
Area of Science:
- Neuro-oncology
- Pediatric neurosurgery
Background:
- Optic pathway/hypothalamic gliomas (OP/HGs) are rare astrocytic tumors, primarily affecting young children.
- They represent 2% of CNS tumors and 3-5% of pediatric intracranial tumors, often presenting with visual disturbances or hypothalamic dysfunction.
- Diagnosis can be delayed due to silent tumor enlargement.
Purpose of the Study:
- To evaluate the efficacy of extended surgical resection for non-NF-1 optic pathway/hypothalamic gliomas (OP/HGs) in pediatric patients.
- To compare surgical outcomes with established chemotherapy protocols.
Main Methods:
- Retrospective analysis of 14 pediatric patients with non-NF-1 OP/HGs who underwent extended resection without adjuvant therapy.
- Median follow-up of 85.5 months.
Main Results:
- Surgical resection demonstrated acceptable middle-term survival, tumor control, and functional outcomes.
- Outcomes were comparable to those achieved with chemotherapy.
Conclusions:
- Extended surgical resection is a viable option for select pediatric OP/HGs, offering comparable results to chemotherapy.
- Chemotherapy, with or without surgery, remains the gold standard for OP/HG management, with treatment plans tailored to tumor origin.
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