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The Association between Galectin-3 and hs-CRP and the Clinical Outcome after Non-ST-Elevation Myocardial Infarction

Milan Pavlović1,2, Svetlana Apostolović1,2, Dragana Stokanović3

  • 1Department of Internal Medicine - Cardiology, Medical Faculty, University of Nis, Bulevar dr Zorana Djindjica 81, Nis, Serbia.

Scientific Reports
|November 10, 2017
PubMed

Insights

In Non-ST elevation myocardial infarction (NSTEMI) patients with atrial fibrillation (AF), galectin-3 and high-sensitivity C-reactive protein (hs-CRP) were elevated. Only hs-CRP predicted adverse outcomes, not galectin-3.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Outcome Prediction

Background:

  • Galectin-3 and hs-CRP are linked to poor outcomes in heart failure and AF.
  • Prognostic value of galectin-3 and hs-CRP in Non-ST elevation acute myocardial infarction (NSTEMI) patients with pre-existing AF is unknown.
  • NSTEMI and AF represent a significant clinical challenge with potential for adverse events.

Purpose of the Study:

  • To investigate the prognostic utility of galectin-3 and hs-CRP in NSTEMI patients with pre-existing AF.
  • To compare galectin-3 and hs-CRP levels and their predictive value for long-term clinical outcomes in NSTEMI patients with and without AF.
  • To identify independent predictors of adverse clinical outcomes in this patient cohort.

Main Methods:

  • Prospective follow-up of 32 NSTEMI patients with AF and 22 NSTEMI patients without AF for 15 months.
  • Measurement of plasma galectin-3 and hs-CRP concentrations at baseline.
  • Statistical analysis to assess the association of biomarkers and clinical factors with composite outcomes.

Main Results:

  • NSTEMI patients with AF had significantly higher galectin-3 and hs-CRP levels compared to those without AF.
  • Galectin-3 plasma concentration was not a significant predictor of composite outcomes (p=0.913).
  • High hs-CRP (above 4.55 mg/L) was associated with a 2.5-fold increased risk of composite outcomes (p<0.05).
  • Creatinine clearance was identified as an independent predictor of unfavorable prognosis.

Conclusions:

  • Galectin-3 and hs-CRP are elevated in NSTEMI patients with AF.
  • hs-CRP, but not galectin-3, showed prognostic value for adverse outcomes in NSTEMI patients with AF.
  • Creatinine clearance is a key independent predictor of long-term prognosis in NSTEMI patients.

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