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High-performance liquid chromatographic determination of trimethoprim in serum
1Department of Clinical Biochemistry, St. Boniface General Hospital, Winnipeg, Manitoba, Canada.
Therapeutic Drug Monitoring
|January 1, 1989
Abstract:
A procedure for determining trimethoprim in serum is reported. It employs the same high-performance liquid chromatographic system described previously for measurement of anticonvulsants, barbiturates, theophylline, caffeine, acetaminophen, and chloramphenicol in serum. The sample preparation for trimethoprim is nearly identical. As a method extension, quantitation of serum trimethoprim on clinical specimens can be easily accommodated as required.