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The association of serum vitamin D concentration and ventricular dysfunction among patients with acute coronary
Kamal Khademvatani1, Mirhosein Seyed Mohammadzad1, Zahra Yekta2
1Department of Cardiology, Shohada Hospital.
Insights
Vitamin D deficiency is linked to a higher risk of ventricular dysfunction in acute coronary syndrome (ACS) patients. This association was notably stronger in individuals with elevated white blood cell (WBC) counts, suggesting a complex interplay.
Area of Science:
- Cardiology
- Endocrinology
- Clinical Research
Background:
- Acute coronary syndrome (ACS) poses significant risks to cardiac function.
- Vitamin D deficiency is a prevalent condition with potential systemic health implications.
- Left ventricular dysfunction is a critical complication following ACS.
Purpose of the Study:
- To investigate the association between vitamin D deficiency and left ventricular dysfunction in ACS patients.
- To explore the potential mediating role of inflammation (CRP, WBC) in this relationship.
- To identify if WBC count modifies the association between vitamin D deficiency and ventricular dysfunction.
Main Methods:
- Cross-sectional study design involving 170 ACS patients.
- Multiple logistic regression analysis to assess the association between vitamin D levels and ventricular performance.
- Evaluation of C-reactive protein (CRP) and white blood cell (WBC) counts as potential mediators.
Main Results:
- Vitamin D deficiency was significantly associated with increased odds of ventricular dysfunction (OR: 2.12, 95% CI: 1.2-5.23).
- White blood cell (WBC) count did not meet mediation criteria but acted as an effect modifier.
- The association between vitamin D deficiency and ventricular dysfunction was pronounced in patients with WBC counts exceeding 11,000.
Conclusions:
- Vitamin D deficiency is independently associated with a higher likelihood of left ventricular dysfunction in ACS patients.
- Inflammation, particularly indicated by WBC count, plays a role in modifying this association.
- Further research, including longitudinal and experimental studies, is warranted to confirm findings and explore vitamin D supplementation as a therapeutic strategy.
Objective:
To determine if vitamin D deficiency was associated with higher odds of left ventricular dysfunction among patients with acute coronary syndrome (ACS) and, if so, to determine whether this association was mediated by increased inflammation as measured by C-reactive protein (CRP) and white blood cell count (WBC).
Methods:
This was a cross-sectional study of 170 participants with ACS. Multiple logistic regression was used to examine the association between the outcome of ventricular performance and serum vitamin D concentrations. We also determined whether CRP and WBC meet standard criteria as the mediators between left ventricular ejection fraction and vitamin D deficiency.
Results:
Participants with vitamin D deficiency were more likely to have ventricular dysfunction (OR: 2.12, 95% CI: 1.2-5.23). WBC counts did not meet one of the criteria for mediation. However, the WBC was an effect modifier such that the association of vitamin D deficiency and ventricular dysfunction was only present among participants with WBC more than 11,000.
Conclusion:
This study found that vitamin D deficiency was associated with higher odds of ventricular dysfunction. Further longitudinal and experimental studies are necessary to confirm this finding and to determine if there is a role for vitamin D supplementation therapy in preventing ventricular dysfunction in select patient populations.
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