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Host responses to concurrent combined injuries in non-human primates
Matthew J Bradley1,2, Diego A Vicente2, Benjamin A Bograd2
1Department of Regenerative Medicine, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910 USA.
Journal of Inflammation (London, England)
|November 10, 2017
Summary
This study developed a realistic large animal trauma model to investigate multi-organ failure (MOF) and the associated inflammatory response. The model successfully induced MOF, providing a platform for future therapeutic research.
Area of Science:
- Trauma and Injury Research
- Inflammatory Response Mechanisms
- Sepsis and Critical Care
Background:
- Multi-organ failure (MOF) post-trauma is a major cause of mortality.
- The underlying abnormal inflammatory response in MOF is not well understood.
- A novel non-human primate model was developed to study trauma-induced MOF.
Purpose of the Study:
- To characterize the inflammatory response in a clinically relevant trauma model.
- To induce multi-organ failure (MOF) in a large animal model.
- To establish a platform for testing novel therapeutic interventions for MOF.
Main Methods:
- Cynomolgus macaques underwent laparoscopy for cecal perforation, liver resection, and soft tissue injury.
- A two-phase treatment protocol (pre-hospital and hospital) was implemented.
- Systemic inflammatory markers (cytokines, chemokines) and tissue inflammation/apoptosis were assessed.
Main Results:
- The model induced significant end-organ damage, indicated by elevated creatinine.
- Systemic levels of key inflammatory mediators (IL-10, IL-6, MCP-1, etc.) increased significantly.
- Pulmonary inflammation, edema, and pneumocyte apoptosis were confirmed in injured animals.
Conclusions:
- A clinically relevant laparoscopic large animal model for multi-trauma and MOF was successfully created.
- This model elicits a significant systemic inflammatory response and MOF.
- The model will facilitate future studies on systemic inflammation and therapeutic testing.
