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Rat Burn Model to Study Full-Thickness Cutaneous Thermal Burn and Infection
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A new model for studying deep partial-thickness burns in rats.

Hui-Fang Guo1, Razana M Ali2, Roslida A Hamid1

  • 1Department of Biomedical Science, Faculty of Medicine and Health Science, University Putra MalaysiaSerdang, Malaysia.

International Journal of Burns and Trauma
|November 10, 2017
PubMed
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This study presents a new, standardized rat model for creating uniform deep partial-thickness burn wounds. This reproducible model is crucial for advancing burn injury research and developing effective treatments.

Area of Science:

  • Biomedical Engineering
  • Wound Healing Research
  • Animal Models in Research

Background:

  • Burn injuries represent a significant global health challenge.
  • Standardized models are critical for reproducible burn research.
  • Existing models may lack consistency in inducing deep partial-thickness burns.

Purpose of the Study:

  • To develop and describe a novel, standardized animal model for inducing deep partial-thickness burns in rats.
  • To establish reproducible conditions for burn induction.
  • To facilitate consistent burn research and therapeutic development.

Main Methods:

  • Deep partial-thickness burns were induced on Sprague-Dawley rats using a custom heating device.
  • Standardized conditions included a contact temperature of 70°C, a 300g device weight, and a 10-second duration.
Keywords:
Animal modeldeep partial-thickness burnmacroscopic evaluationmicroscopic evaluation

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  • Macroscopic (digital imaging) and histological (hematoxylin-eosin staining) evaluations were performed over 21 days.

    • Main Results:

    • The model successfully produced uniform deep partial-thickness burns in rats.
    • Macroscopic evaluation documented burn appearance and wound contraction.
    • Wound contraction reached 90.39% of the original area by day 21; histological analysis revealed healing processes.

    Conclusions:

    • A standardized and reproducible rat model for deep partial-thickness burns has been established.
    • This model provides a reliable platform for studying burn wound healing and testing interventions.
    • The findings support the utility of this model in advancing burn injury research.