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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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Cardiac manifestations of Familial Mediterranean fever

Ahmad Alsarah1, Osama Alsara2, Heather S Laird-Fick1

  • 1Department of Internal Medicine, Michigan State University, East Lansing, MI, USA.

Avicenna Journal of Medicine
|November 10, 2017
PubMed

Insights

Familial Mediterranean Fever (FMF) can cause serious cardiovascular issues like pulmonary hypertension due to chronic inflammation and amyloid deposits. Colchicine therapy may help prevent and treat these FMF-related heart conditions.

Area of Science:

  • Cardiology
  • Rheumatology
  • Genetics

Background:

  • Familial Mediterranean Fever (FMF) is an autoinflammatory disorder.
  • Characterized by recurrent fever, serositis (peritonitis, pleuritis), and arthritis.
  • Increasingly reported globally due to population migration.

Purpose of the Study:

  • To analyze cardiovascular manifestations in FMF patients.
  • Investigate the link between FMF and various heart conditions.
  • Review the role of colchicine in managing cardiac involvement.

Main Methods:

  • PubMed search using keywords: "Familial Mediterranean Fever" or "FMF" combined with cardiovascular terms.
  • Analysis of existing data on cardiac involvement in FMF.
  • Review of pathophysiological mechanisms and treatment outcomes.

Main Results:

  • FMF is associated with diverse cardiovascular conditions.
  • Mechanisms include chronic inflammation and amyloid deposition.
  • Pulmonary hypertension is a severe manifestation with poor prognosis.

Conclusions:

  • Cardiovascular involvement is a significant concern in FMF patients.
  • Early detection and management are crucial.
  • Colchicine shows promise in preventing and treating cardiac manifestations.
Keywords:
Atherosclerosiscardiomyopathycoronary artery diseasefamilial mediterranean feverpericarditis

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