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Related Experiment Video

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Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery
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Endovascular Ischemic Stroke Models in Nonhuman Primates.

Di Wu1,2,3, Ankush Chandra4,5, Jian Chen1,6

  • 1China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.

Neurotherapeutics : the Journal of the American Society for Experimental Neurotherapeutics
|November 10, 2017
PubMed
Summary
This summary is machine-generated.

Nonhuman primates (NHPs) are recommended for preclinical stroke research. Endovascular methods in NHPs effectively model human ischemic stroke, offering valuable insights for translational studies.

Keywords:
Ischemic strokeanimal modelnonhuman primateprognosisthrombolysis

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Area of Science:

  • Neuroscience
  • Translational Medicine
  • Medical Imaging

Background:

  • Rodent models have limitations in mimicking human stroke.
  • The Stroke Therapy Academic Industry Roundtable recommends nonhuman primates (NHPs) for preclinical stroke studies.
  • Ischemic stroke, often caused by vessel occlusion, leads to brain infarction.

Purpose of the Study:

  • To review transient or permanent cerebral blood vessel occlusions in NHPs using endovascular methods.
  • To analyze the advantages, disadvantages, and applications of these NHP stroke models.
  • To further analyze models based on emboli type, occlusion site, infarct size, hemodynamics, and dysfunction.

Main Methods:

  • Review of endovascular methods for inducing cerebral blood vessel occlusion in NHPs.
  • Analysis of different embolic materials and occlusion locations.
  • Evaluation of infarct size, hemodynamic changes, and resulting dysfunctions.

Main Results:

  • Endovascular methods in NHPs closely mimic thromboembolic/thrombotic cerebrovascular occlusion in human patients.
  • Various models allow for the analysis of specific stroke facets.
  • Detailed analysis of model parameters including emboli, occlusion site, infarct size, hemodynamics, and dysfunction.

Conclusions:

  • Experimental ischemic stroke models in NHPs, particularly those induced by endovascular methods, are valuable tools for preclinical research.
  • These models provide a bridge between rodent studies and human stroke conditions.
  • NHP models are crucial for advancing translational stroke research and therapy development.