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Updated: Feb 19, 2026
09:43
Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
Published on: October 14, 2019
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Multifocality in Small Bowel Neuroendocrine Tumors
Alexandra Gangi1, Emily Siegel1, Galinos Barmparas1
1Department of Surgery, Division of Surgical Oncology and Hepatobiliary Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Summary
Multifocal small bowel neuroendocrine tumors (SBNETs) are common, with over half of patients presenting with multiple lesions. However, multifocality does not affect survival or recurrence rates in patients with SBNETs.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Endocrinology
Background:
- Neuroendocrine tumors (NETs) represent a significant portion of small bowel (SB) neoplasms.
- Primary small bowel neuroendocrine tumors (SBNETs) are increasingly recognized as a clinical challenge.
Purpose of the Study:
- To determine the incidence of multifocality in SBNETs.
- To evaluate the impact of multifocality on patient outcomes, including survival and recurrence.
- To assess the utility of double-balloon enteroscopy (DBE) and capsule endoscopy in detecting multifocal SBNETs.
Main Methods:
- A retrospective review of patients with SBNETs who underwent surgical intervention.
- Comparison of outcomes between patients with multifocal SBNETs and those with solitary lesions.
- Evaluation of diagnostic yield of DBE and capsule endoscopy for multifocal SBNET detection.
Main Results:
- Of 85 included patients, 54.1% had multifocal SBNETs, predominantly in the ileum.
- Double-balloon enteroscopy (DBE) identified additional lesions in 62.2% of cases, with 82.1% confirmed as NET.
- No significant differences in survival or recurrence were observed between multifocal and solitary SBNET groups.
Conclusions:
- Multifocality is a frequent characteristic of SBNETs.
- DBE is valuable for preoperative detection of multifocal SBNETs.
- Multifocality does not appear to influence the prognosis of SBNET patients.
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