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Tricalycoside, a New Cerebroside from Tricalysia coriacea (Rubiaceae)
Maurice D Awouafack1,2, Pierre Tane1, Hiroyuki Morita2
1Laboratory of Natural Products Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
Abstract:
A new cerebroside, named as tricalycoside (1), was isolated from the CH2 Cl2 /MeOH (1:1) extract of twigs and leaves of Tricalysia coriacea using repeated silica gel open column chromatography followed by preparative TLC and Sephadex LH-20, together with six known compounds (2 - 7). The structure of the new compound was determined by analysis of 1D- and 2D-NMR, MS data, chemical conversion, and by comparison of these data with those from the literature. Tricalycoside (1) possessed a weak antibacterial activity against Klebsiella pneumoniae (MIC = 75 μg/mL).
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