A framework for designing patient-specific bioprosthetic heart valves using immersogeometric fluid-structure...

Area of Science:

• Biomedical Engineering
• Computational Mechanics
• Medical Imaging

Background:

• Cardiovascular diseases pose significant mortality risks.
• Patient-specific surgical planning and device design can improve outcomes.
• Computational mechanics models from medical images offer potential for personalized treatments.

Purpose of the Study:

• To present a novel framework for designing prosthetic heart valves.
• To utilize a parametric design platform and fluid-structure interaction (FSI) analysis.
• To enable patient-specific surgical planning and customized medical device design.

Main Methods:

• Parameterization of prosthetic heart valve leaflet geometry.
• Reconstruction of patient-specific aortic root from medical imaging data.
• Hybrid arbitrary Lagrangian-Eulerian/immersogeometric FSI methodology for simulating blood flow and valve-aorta interaction.

Main Results:

• Generation of diverse leaflet designs based on key parameters.
• Analysis of heart valve performance metrics like effective orifice area and coaptation area.
• Validation of simulation results against patient-specific phase contrast magnetic resonance imaging (PC-MRI) data.

Conclusions:

• The developed framework facilitates patient-specific prosthetic heart valve design.
• The FSI analysis accurately simulates the complex interactions between the valve, aorta, and blood flow.
• This approach holds promise for reducing cardiovascular disease morbidity and mortality through improved surgical planning and device customization.