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Related Experiment Videos

Time-related decrease in sensitivity to ergonovine in patients with variant angina.

M Previtali1, C Panciroli, R De Ponti

  • 1Department of Internal Medicine, University of Pavia, Italy.

American Heart Journal
|January 1, 1989
PubMed
Summary
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Variant angina patients showed decreasing sensitivity to ergonovine over time, despite a consistent correlation between ergonovine test results and disease activity. This suggests the ergonovine test is valuable for tracking vasospastic angina evolution.

Area of Science:

  • Cardiology
  • Clinical Medicine
  • Pharmacology

Background:

  • Variant angina, also known as vasospastic angina, is characterized by reversible coronary artery vasospasm.
  • Calcium antagonists are a primary treatment for variant angina.
  • The ergonovine test is used to provoke coronary artery vasospasm and diagnose variant angina.

Purpose of the Study:

  • To evaluate long-term changes in ergonovine test response in patients with variant angina.
  • To assess the relationship between ergonovine test results and spontaneous disease activity over time.
  • To determine the utility of the ergonovine test in monitoring the natural evolution of vasospastic angina.

Main Methods:

  • Serial ergonovine provocation tests and Holter monitoring were performed on 18 patients with variant angina.

Related Experiment Videos

  • Patients had a positive ergonovine test and responded favorably to calcium antagonists.
  • Follow-up assessments were conducted at 3, 6, and 12 months.

    • Main Results:

    • The proportion of patients with a positive ergonovine test decreased significantly over 12 months (100% to 29%).
    • A progressive increase in the mean ergonovine dose and ST segment depression was observed during follow-up.
    • Ergonovine test results remained well-correlated with spontaneous disease activity throughout the study period (94% to 71%).

    Conclusions:

    • Patients with variant angina treated with calcium antagonists develop a time-related decrease in sensitivity to ergonovine.
    • The ergonovine test remains a useful tool for assessing the natural course of vasospastic angina.
    • The correlation between ergonovine test findings and disease activity highlights its clinical relevance in long-term management.