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15(S)15 METHYL PGF2α BY INTRAMUSCULAR ROUTE AT TWO HOURLY INTERVAL FOLLOWED BY THREE HOURLY FOR INDUCTION OF SECOND
Acta Obstetricia Et Gynecologica Scandinavica
|November 10, 2017
Summary
Prostin 15M effectively induced abortion in 85.7% of patients during the second trimester. Prophylactic antiemetics and antidiarrheals reduced side effects, with no serious complications observed.
Area of Science:
- Obstetrics and Gynecology
- Reproductive Medicine
- Pharmacology
Background:
- Second-trimester abortion methods require careful consideration for efficacy and safety.
- Prostaglandins are commonly used to induce abortion, but side effects can impact patient experience.
Purpose of the Study:
- To evaluate the efficacy and safety of Prostin 15M (carboprost tromethamine) for second-trimester abortion.
- To assess the impact of prophylactic antiemetic and antidiarrheal medications on side effect incidence.
Main Methods:
- A multicenter trial involving 322 patients undergoing second-trimester abortion.
- Intramuscular Prostin 15M administered at 250 µg every two hours until 1 cm cervical dilation, then every three hours.
- Mean dosage, induction-abortion interval, and complication rates were recorded.
Main Results:
- An overall abortion success rate of 85.7% was achieved.
- Primigravidae had a higher failure rate (22.6%) compared to multigravidae (9.6%).
- Prophylactic loperamide and emidoxyn reduced vomiting and diarrhea incidence from 3.0/4.1 to 1.6/1.7 episodes, respectively. Mean blood loss was 25.4 ml.
Conclusions:
- Prostin 15M is an effective agent for second-trimester abortion induction.
- Concurrent use of antiemetics and antidiarrheals can mitigate common gastrointestinal side effects.
- The treatment demonstrated a favorable safety profile with no severe complications.
