STUDIES ON 15(S)15 METHYL PGF_2α BY INTRAMUSCULAR ROUTE FOR SECOND TRIMESTER ABORTION (TWO HOURLY SCHEDULE)

Area of Science:

• Obstetrics and Gynecology
• Reproductive Medicine
• Pharmacology

Background:

• Second-trimester abortion induction requires effective and safe methods.
• Prostaglandins are commonly used for labor induction.
• 15(S)15 methyl prostaglandin F2α (PGF2α) is a synthetic prostaglandin analogue.

Purpose of the Study:

• To evaluate the efficacy and safety of intramuscular 15(S)15 methyl PGF2α for second-trimester abortion induction.
• To compare outcomes between primigravidae and multigravidae patients.

Main Methods:

• A multicenter study involving 97 patients undergoing second-trimester abortion.
• Patients received premedication with Imodium and Perinorm to manage side effects.
• Intramuscular Prostin 15M (250 µg) was administered every two hours, with abortion progress assessed before each dose.
• Treatment failure was defined as no progress after 10 injections.

Main Results:

• The treatment successfully induced abortion in 24/39 primigravidae and 52/58 multigravidae.
• Mean induction-abortion intervals were 17.8 hours for primigravidae and 14.5 hours for multigravidae.
• The overall incidence of incomplete abortion was 17.1%.
• Gastrointestinal side effects, including vomiting and diarrhea, were observed, with a slightly higher incidence in primigravidae.

Conclusions:

• Intramuscular 15(S)15 methyl PGF2α is an effective agent for second-trimester abortion induction.
• Multigravidae patients achieved abortion more rapidly than primigravidae.
• Careful management of gastrointestinal side effects is necessary during treatment.