PROPHYLACTIC USE OF 15(S)15 METHYL PGF_2α BY INTRAMUSCULAR ROUTE FOR CONTROL OF POSTPARTUM BLEEDING - A COMPARATIVE...

Area of Science:

• Obstetrics and Gynecology
• Pharmacology

Background:

• Postpartum hemorrhage remains a leading cause of maternal mortality worldwide.
• Effective prophylactic management of the third stage of labor is crucial for preventing excessive blood loss.

Purpose of the Study:

• To compare the efficacy and safety of 15(S)15 methyl prostaglandin F2α (Prostin 15M) with methylergometrine for prophylactic control of postpartum bleeding.
• To evaluate the impact of these agents on the duration of the third stage of labor.

Main Methods:

• A multicentre trial involving 300 patients undergoing labor.
• Patients were randomized to receive either an intramuscular injection of 125 µg Prostin 15M or methylergometrine.
• Key outcomes measured included the duration of the third stage of labor and estimated blood loss.

Main Results:

• The duration of the third stage of labor was significantly shorter in the Prostin 15M group (4.4 minutes) compared to the methylergometrine group (8.6 minutes).
• Mean blood loss during the third stage was reduced by approximately 50% in the Prostin 15M group (72 ml) versus the methylergometrine group (145 ml).

Conclusions:

• Prostin 15M demonstrated superior efficacy over methylergometrine in prophylactically controlling blood loss during the third stage of labor.
• The use of Prostin 15M resulted in a shorter duration of the third stage of labor, suggesting improved management of postpartum bleeding.