INTRAMUSCULAR 15(S)15 METHYL PGF_2α FOR MENSTRUAL REGULATION

Area of Science:

• Reproductive Medicine
• Pharmacology

Background:

• Early pregnancy termination methods are crucial for reproductive health.
• Prostaglandins are widely used for medical induction of abortion.

Purpose of the Study:

• To evaluate the safety and efficacy of 15(S)15 methyl PGF2α (Prostin 15M) for inducing menses in early pregnancy.
• To determine the success rate and side effects of intramuscular Prostin 15M.

Main Methods:

• A multicentre trial involving 284 women with early pregnancy (up to 49 days).
• Patients received two intramuscular doses of 0.5 mg Prostin 15M.
• Antiemetic and antidiarrhoeal medications were administered prior to prostaglandin analogue.

Main Results:

• An overall success rate of 87.7% for complete abortion was observed at two weeks.
• Higher success rates of 92% up to 42 days and 100% up to 35 days of amenorrhea were recorded.
• Gastrointestinal side effects, primarily vomiting and diarrhea, were mild and transient.

Conclusions:

• Intramuscular Prostin 15M is an effective treatment for inducing menses in early pregnancy.
• Efficacy is notably high when the duration of amenorrhea is 35 days or less.
• The treatment is generally safe, with manageable side effects.