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Cyclin D1, Ret and P27 Expression in Papillary Thyroid Microcarcinoma
Ana Barić1, Vinko Marković1, Davor Eterović1
1Clinical Department of Nuclear Medicine, Split University Hospital Center, Split
Acta Clinica Croatica
|November 10, 2017
Summary
This study investigated RET, p27, and cyclin D1 in papillary microcarcinoma. p27 expression was significantly associated with lymph node metastases, highlighting its importance in assessing tumor behavior.
Area of Science:
- Oncology
- Molecular Biology
- Pathology
Background:
- Papillary microcarcinoma is a common thyroid cancer.
- Understanding molecular markers predicting metastasis is crucial for patient management.
Purpose of the Study:
- To determine the influence of RET, p27, and cyclin D1 expression on regional lymph node metastases in papillary microcarcinoma.
- To assess the utility of these markers in predicting tumor behavior.
Main Methods:
- Analysis of 70 papillary microcarcinoma cases.
- Immunohistochemistry for RET, p27, and cyclin D1 expression.
- Statistical analysis including chi-squared and Fisher exact tests.
Main Results:
- No significant association between RET expression and lymph node metastases.
- Cyclin D1 expression showed a statistically significant association with lymph node metastases (p=0.021).
- p27 expression demonstrated a significant correlation with lymph node metastasis (p=0.124).
Conclusions:
- p27 expression is a significant predictor of lymph node metastasis in papillary microcarcinoma.
- Evaluation of RET, p27, and cyclin D1 expression is valuable for assessing microcarcinoma behavior.
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