Laboratory evolution of protein conformational dynamics
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Updated: Feb 19, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
Eleanor C Campbell1, Galen J Correy1, Peter D Mabbitt1
1Research School of Chemistry, Australian National University, Canberra, ACT 2601, Australia.
Abstract:
This review focuses on recent work that has begun to establish specific functional roles for protein conformational dynamics, specifically how the conformational landscapes that proteins can sample can evolve under laboratory based evolutionary selection. We discuss recent technical advances in computational and biophysical chemistry, which have provided us with new ways to dissect evolutionary processes. Finally, we offer some perspectives on the emerging view of conformational dynamics and evolution, and the challenges that we face in rationally engineering conformational dynamics.
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