MicroRNAs participate in the regulation of oligodendrocytes development in white matter injury

Related Experiment Video

Updated: Feb 19, 2026

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments
09:05

Generation of Oligodendrocytes and Oligodendrocyte-Conditioned Medium for Co-Culture Experiments

Published on: February 9, 2020

11.1K

Dongqiong Xiao1, Yi Qu1, Lingli Pan1

  • 1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

Reviews in the Neurosciences
|November 10, 2017
PubMed

Insights

MicroRNAs (miRNAs) are key regulators of oligodendrocyte development. Understanding their role in white matter injury (WMI) offers new therapeutic targets for cognitive and motor disorders.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • White matter injury (WMI) is a significant cause of neurological deficits, including cognitive impairment and cerebral palsy.
  • Oligodendrocyte (OL) development is critical for white matter integrity, and its dysregulation is a hallmark of WMI.

Purpose of the Study:

  • To review the current understanding of microRNA (miRNA) involvement in oligodendrocyte development.
  • To explore the role of miRNA dysregulation in the pathogenesis of WMI.
  • To highlight the potential of miRNAs as therapeutic targets for WMI.

Main Methods:

  • Literature review of studies investigating miRNAs and oligodendrocyte development.
  • Analysis of research on miRNA dysregulation in the context of WMI.
  • Synthesis of findings to identify molecular mechanisms and therapeutic strategies.

Main Results:

  • miRNAs are crucial regulators of oligodendrocyte differentiation and maturation.
  • Aberrant miRNA expression is implicated in the pathogenesis of WMI.
  • Specific miRNAs have been identified as key players in OL development and WMI.

Conclusions:

  • miRNAs represent a critical molecular link between OL development and WMI.
  • Targeting miRNAs offers a promising avenue for novel WMI prevention and treatment strategies.
  • Further research into miRNA-mediated pathways is essential for clinical translation.
Keywords:
developmentalmicroRNAsoligodendrocytewhite matter injury

More Related Videos

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning11:11

Preparation of Rat Oligodendrocyte Progenitor Cultures and Quantification of Oligodendrogenesis Using Dual-infrared Fluorescence Scanning

Published on: February 17, 2016

12.5K
Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

10.4K

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.8K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.3K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.1K