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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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Immunotherapy for kidney cancer: status quo and the future

Jens Bedke1, Viktoria Stühler1, Arnulf Stenzl1

  • 1Department of Urology, Eberhard Karls University, Tübingen, Germany.

Current Opinion in Urology
|November 10, 2017
PubMed
Abstract

Insights

Immune checkpoint inhibitors (ICI) are revolutionizing advanced renal cell carcinoma treatment, showing improved survival. Combinations of ICI with other therapies are promising for future metastatic renal cell carcinoma management.

Area of Science:

  • Oncology
  • Immunotherapy
  • Renal Cell Carcinoma Research

Background:

  • The treatment paradigm for advanced and metastatic renal cell carcinoma (RCC) is evolving.
  • Traditional therapies like tyrosine kinase inhibitors (TKI) and mTOR inhibitors are being supplemented by novel immunooncology agents.

Purpose of the Study:

  • To review recent advancements in immunooncology for advanced and metastatic RCC.
  • To analyze clinical trial results from the past 12 months.

Main Methods:

  • Literature review of recent immunooncology developments.
  • Analysis of phase III trial outcomes for immune checkpoint inhibitors (ICI) and combinations.
  • Evaluation of early-phase trials for novel therapeutic combinations.

Main Results:

  • Immune checkpoint inhibitors (ICI) as monotherapy (nivolumab) and in combination (nivolumab and ipilimumab) show prolonged overall survival in phase III trials.
  • Combination of ICI (atezolizumab) with bevacizumab demonstrated improved progression-free survival (PFS) in PD-L1 positive subgroups.
  • Early trials suggest promise for ICI and TKI combinations, with ongoing phase III studies.

Conclusions:

  • The treatment landscape for metastatic RCC (mRCC) is increasingly dominated by immunooncology agents.
  • ICI monotherapy and combinations are gaining clinical traction.
  • Future treatments may involve novel combinations of ICI with TKIs, vaccines, and metabolic immune checkpoint inhibitors.

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