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Updated: Feb 19, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Case Report: Masquerading Large-vessel Giant Cell Arteritis.

Paul Jacquier¹, Raphael Wuarin¹, Carlo Chizzolini²

¹Ophthalmology Service, University Hospitals and School of Medicine, Geneva, Switzerland.

Optometry and Vision Science : Official Publication of the American Academy of Optometry

|November 10, 2017

Summary

This summary is machine-generated.

Large-vessel giant cell arteritis (GCA) can present with unusual ophthalmic issues like sequential vision loss. Early diagnosis and treatment are crucial for managing this rare form of GCA.

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Area of Science:

Ophthalmology
Rheumatology
Vascular Medicine

Background:

Giant cell arteritis (GCA) typically affects cranial arteries, posing diagnostic challenges when presenting atypically.
Large-vessel GCA involves proximal aortic branches and can be underdiagnosed, especially with ocular manifestations.

Observation:

A case of a 65-year-old woman with sequential bilateral anterior ischemic optic neuropathy and branch retinal artery occlusion is presented.
The patient lacked typical cranial GCA symptoms, complicating initial diagnosis.

Findings:

Extensive workup, including temporal artery biopsy, was inconclusive for GCA.
Positron emission tomography revealed hypermetabolism in the aorta, confirming large-vessel GCA.
A coincidentally discovered breast tumor was excised.

Implications:

This case highlights the importance of considering large-vessel GCA in patients with unexplained ocular vascular events.
Ophthalmologists must be aware of atypical GCA presentations to ensure timely diagnosis and treatment.
Prompt recognition and management of large-vessel GCA can prevent further vision loss and systemic complications.