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Related Experiment Videos

Zinc absorption in human small intestine.

H H Lee1, A S Prasad, G J Brewer

  • 1Department of Internal Medicine, University of Michigan, Medical Center, Ann Arbor 48109.

The American Journal of Physiology
|January 1, 1989
PubMed
Summary

Zinc absorption occurs throughout the small intestine, with the jejunum showing the highest rate. Zinc absorption is concentration-dependent and interacts with glucose transport, suggesting a carrier-mediated process.

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Area of Science:

  • Gastroenterology
  • Human Physiology
  • Nutritional Science

Background:

  • Understanding the precise location and mechanisms of zinc absorption in the human intestine is crucial for nutritional science.
  • Previous studies have indicated varying absorption rates across different intestinal segments, but detailed interactions with other nutrients remain to be fully elucidated.

Purpose of the Study:

  • To determine the specific intestinal sites of zinc absorption in humans.
  • To investigate the interactions between intestinal zinc absorption and the absorption of other solutes, such as glucose, sodium, and water.
  • To explore the concentration dependency and potential transport mechanisms of zinc absorption.

Main Methods:

  • Employed the triple-lumen steady-state perfusion technique in twenty-one healthy human subjects.

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  • Administered balanced electrolyte solutions containing varying concentrations of zinc acetate throughout the small intestine (duodenum, jejunum, ileum).
  • Assessed the absorption rates of zinc, glucose, sodium, and water under different perfusion conditions, including the presence of glucose and varying zinc concentrations.

    • Main Results:

    • Zinc absorption was observed throughout the entire small intestine, with the highest absorption rate in the jejunum (357 nM/min/40 cm), followed by the duodenum (230 nM/min/40 cm) and ileum (84 nM/min/40 cm).
    • Zinc absorption demonstrated a linear increase with increasing zinc concentrations in the jejunum.
    • Co-administration of glucose significantly stimulated zinc absorption, and conversely, zinc enhanced glucose absorption, indicating a coupled transport mechanism. Water and sodium absorption were not increased but decreased with higher zinc concentrations.

    Conclusions:

    • Zinc absorption occurs throughout the small intestine, with a preferential site in the jejunum.
    • Zinc absorption is concentration-dependent and appears to be mediated by a carrier system, as evidenced by its interaction with glucose transport.
    • These findings provide critical insights into the physiological regulation of zinc homeostasis and nutrient interactions within the human gastrointestinal tract.