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Related Concept Videos

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Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
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Stem cell-based bone regeneration in diseased microenvironments: Challenges and solutions.

Bing-Dong Sui1, Cheng-Hu Hu2, An-Qi Liu3

  • 1State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China; Research and Development Center for Tissue Engineering, The Fourth Military Medical University, Xi'an, Shaanxi 710032, China.

Biomaterials
|November 11, 2017
PubMed
Summary

Mesenchymal stem cells (MSCs) hold promise for bone healing but face challenges in diseased environments. Strategies are emerging to enhance MSC efficacy for bone regeneration in aging and disease.

Keywords:
Bone healingCell mobilizationCytotherapyMesenchymal stem cellsMicroenvironmental regulationTissue engineering

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Cell Biology

Background:

  • Extensive bone loss presents a significant clinical challenge.
  • Mesenchymal stem cells (MSCs) show potential for bone healing through endogenous mobilization and transplantation.
  • The efficacy of MSCs is often compromised by diseased host microenvironments.

Purpose of the Study:

  • To review the applications and challenges of MSC-mediated bone healing.
  • To explore strategies for optimizing MSC-based bone regeneration in aging and disease.
  • To discuss novel solutions addressing MSC dysfunction in pathological conditions.

Main Methods:

  • Review of current literature on MSCs in bone regeneration.
  • Analysis of factors affecting MSC function in diseased microenvironments.
  • Evaluation of emerging strategies for enhancing MSC-based therapies.

Main Results:

  • MSC-mediated bone healing faces hurdles due to host comorbidities.
  • Diseased microenvironments negatively impact MSC function and therapeutic outcomes.
  • Novel approaches include enhancing MSC resistance and utilizing cell-free therapies.

Conclusions:

  • Optimizing MSC function in challenging microenvironments is crucial for successful bone regeneration.
  • Strategies like improving MSC resilience and using MSC-derived vesicles offer promising therapeutic avenues.
  • Further research is needed to fully harness MSC potential for skeletal repair in aging and disease.