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Neutrophils in Gliomas.

Matteo Massara1,2, Pasquale Persico1, Ornella Bonavita1,2

  • 1Humanitas Clinical and Research Center, Rozzano, Italy.

Frontiers in Immunology
|November 11, 2017
PubMed
Summary

Neutrophils, abundant white blood cells, play a dual role in gliomas, potentially promoting or fighting tumors. Understanding their function is key to developing new glioma cancer therapies.

Keywords:
cancer immunotherapychemokinesgliomaimmunotherapyinflammation and cancerneutrophils

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Area of Science:

  • Oncology
  • Immunology
  • Neuroscience

Background:

  • Neutrophils are key immune cells at inflammatory sites and within the tumor microenvironment.
  • Their role in gliomas is complex, exhibiting both anti-tumoral and pro-tumoral activities based on activation state.
  • Increased neutrophil presence in human gliomas correlates with disease severity.

Purpose of the Study:

  • To review current knowledge on neutrophil involvement in glioma.
  • To explore the dual role of neutrophils in glioma progression and anti-cancer immunity.
  • To discuss the potential of neutrophils in novel glioma treatment strategies.

Main Methods:

  • Literature review of preclinical and clinical studies on neutrophils in glioma.
  • Analysis of the impact of neutrophil maturation and activation states on glioma.
  • Examination of neutrophil-mediated anti-angiogenic therapy resistance.

Main Results:

  • Neutrophils can promote glioma growth and resistance to anti-angiogenic therapies in preclinical models.
  • Neutrophil infiltration correlates with glioma severity, suggesting a prognostic role.
  • Emerging evidence shows neutrophils can be activated for direct tumor cell killing and anti-tumor responses.

Conclusions:

  • Neutrophils have a significant, context-dependent role in glioma pathogenesis.
  • Targeting neutrophil functions presents a promising avenue for improving glioma therapies.
  • Further research is needed to harness neutrophils for effective anti-glioma strategies.