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Short-term pulmonary function change in association with ozone levels.

P L Kinney1, J H Ware, J D Spengler

  • 1Department of Environmental Science and Physiology, Harvard School of Public Health, Boston, MA 02115.

The American Review of Respiratory Disease
|January 1, 1989
PubMed
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Short-term exposure to ambient ozone, even below national standards, is linked to temporary declines in children's lung function (FVC, FEV75, MMEF, Vmax75). Particulate matter did not show a significant association.

Area of Science:

  • Environmental Health
  • Pulmonary Medicine
  • Epidemiology

Background:

  • Air pollution poses a significant threat to respiratory health, particularly in vulnerable populations like children.
  • Previous studies have indicated potential links between air pollutants and reduced lung function, but specific pollutant effects and population responses require further investigation.

Purpose of the Study:

  • To investigate the association between short-term ambient air pollution exposure, specifically ozone and particulate matter, and pulmonary function in school children.
  • To determine if temperature also influences short-term changes in lung function.

Main Methods:

  • Repeated pulmonary function measurements (FVC, FEV75, MMEF, Vmax75) were collected weekly from 154 school children over two months.
  • Concurrent measurements of ambient ozone, fine particle, and fine sulfate concentrations were recorded.

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  • Child-specific linear regressions were used to analyze the relationship between pulmonary function changes and air pollution or temperature.

    • Main Results:

    • Decreased lung function (FVC, FEV75, MMEF, Vmax75) was associated with ambient ozone exposure.
    • No significant association was found between particulate matter levels and lung function decrements.
    • Decreases in FVC, MMEF, and Vmax75 were also associated with higher temperatures.

    Conclusions:

    • Ambient ozone exposure, even at levels below the National Ambient Air Quality Standard (120 ppb), is associated with transient decreases in lung function in children.
    • The long-term health implications of these transient lung function changes remain uncertain.
    • Individual responses to ozone were not found to be related to sex, asthma, early respiratory illness, or airway size.