Related Experiment Video

Updated: Feb 19, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.7K

Red cell and platelet distribution widths in patients with angina pectoris and acute myocardial infarction

Moriyuki Terakura1, Toshimasa Sugawara1, Daisuke Hirota1

  • 1Department of Emergency Medicine Teikyo University School of Medicine Tokyo Japan.

Acute Medicine & Surgery
|November 11, 2017
PubMed

Insights

Elevated red cell and platelet distribution widths at onset are linked to acute myocardial infarction. These markers, particularly platelet distribution width, show promise for early detection and prevention strategies.

Area of Science:

  • Cardiology
  • Hematology
  • Diagnostic Medicine

Background:

  • Acute myocardial infarction (AMI) is a leading cause of mortality worldwide.
  • Early detection and prevention of AMI are crucial for improving patient outcomes.
  • Biomarkers that can predict AMI onset are of significant clinical interest.

Purpose of the Study:

  • To investigate the relationship between red cell distribution width (RDW) and platelet distribution width (PDW) and the occurrence of AMI.
  • To assess the potential of RDW and PDW as early indicators for AMI detection.

Main Methods:

  • A retrospective analysis was conducted on 46 patients with stable angina pectoris and 140 patients with AMI.
  • RDW and PDW were measured using an automated blood cell analyzer.
  • Values obtained at onset and before onset were compared between the AMI and angina pectoris groups.

Main Results:

  • At onset, both RDW and PDW were significantly higher in the AMI group compared to the angina pectoris group.
  • Specifically, RDW was 46.4% vs 44.5% and PDW was 12.1 fL vs 11.1 fL in AMI vs angina groups, respectively.
  • While RDW before onset did not differ, PDW before onset was higher in the AMI group.

Conclusions:

  • RDW and especially PDW may serve as valuable markers for the early detection of AMI.
  • Further research could explore the integration of RDW and PDW into diagnostic algorithms for AMI.
  • These findings support the potential utility of RDW and PDW in risk stratification for cardiovascular events.
Abstract

Keywords:
Angina pectorismyocardial infarctionplateletred cell distribution width

More Related Videos

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

1.7K
Simultaneous 3D Analysis of Cardiac Damage and Immune Response in Reperfused Acute Myocardial Infarction Using Light Sheet Fluorescence Microscopy06:38

Simultaneous 3D Analysis of Cardiac Damage and Immune Response in Reperfused Acute Myocardial Infarction Using Light Sheet Fluorescence Microscopy

Published on: September 26, 2025

1.2K

Related Concept Videos

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
477
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.1K
Angina I: Introduction01:30

Angina I: Introduction

Definition and Symptoms: Angina (angina pectoris) is chest pain or discomfort caused by myocardial ischemia, which occurs when the heart muscle receives insufficient oxygen-rich blood. It typically manifests as pressing, squeezing, or crushing sensations in the chest and may radiate to the shoulders, arms, neck, jaw, or back.Primary Cause: In a healthy state, the coronary arteries can dilate (widen) to increase blood flow and meet the increased oxygen demand during physical activity or...
572
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
309
Angina II: Classification01:27

Angina II: Classification

Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
436
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
328