Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.7K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.7K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

2.2K
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
2.2K
Long-term Depression01:03

Long-term Depression

3.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.4K
Long-term Depression01:05

Long-term Depression

33.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

1.3K
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
1.3K
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

1.7K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

mGluR1 signaling is necessary for strengthening winner climbing fiber inputs in the developing mouse cerebellum.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Membrane topology inversion of GGCX mediates cytoplasmic carboxylation for antiviral defense.

Science (New York, N.Y.)·2025
Same author

Molecular and Anatomical Strengthening of "Winner" Climbing Fiber Synapses in Developing Mouse Purkinje Cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same author

Distinct release properties of glutamate/GABA co-transmission serve as a frequency-dependent filtering of supramammillary inputs.

eLife·2024
Same author

Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats.

Proceedings of the National Academy of Sciences of the United States of America·2023
Same author

Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study.

Molecular brain·2023

Related Experiment Video

Updated: Feb 19, 2026

Localization of the Locus Coeruleus in the Mouse Brain
07:44

Localization of the Locus Coeruleus in the Mouse Brain

Published on: March 7, 2019

19.2K

Locus Coeruleus and Dopamine-Dependent Memory Consolidation.

Miwako Yamasaki1, Tomonori Takeuchi1,2

  • 1Department of Anatomy, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan.

Neural Plasticity
|November 11, 2017
PubMed
Summary

Novelty enhances memory retention via dopamine D1/D5 receptors in the hippocampus. This review explores the locus coeruleus

More Related Videos

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

12.6K
Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

27.6K

Related Experiment Videos

Last Updated: Feb 19, 2026

Localization of the Locus Coeruleus in the Mouse Brain
07:44

Localization of the Locus Coeruleus in the Mouse Brain

Published on: March 7, 2019

19.2K
Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood
08:20

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

12.6K
Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory
08:08

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

27.6K

Area of Science:

  • Neuroscience
  • Memory Consolidation
  • Synaptic Plasticity

Background:

  • Most everyday memories formed in the hippocampus are forgotten.
  • Memory retention is enhanced by novelty shortly before or after encoding.
  • Dopamine (DA) signaling via D1/D5 receptors in the hippocampus is crucial for memory persistence and novelty-associated memory enhancement.

Purpose of the Study:

  • To review key findings on D1/D5 receptor-dependent synaptic plasticity and memory persistence in the hippocampus.
  • To highlight the role of the locus coeruleus (LC) in DA-dependent memory consolidation.
  • To discuss mechanisms underlying novelty-associated memory enhancement.

Main Methods:

  • Review of existing scientific literature.
  • Analysis of evidence for D1/D5 receptor function in memory.
  • Examination of the LC-DA system's role in novelty detection and memory consolidation.

Main Results:

  • D1/D5 receptor signaling in the hippocampus is essential for memory persistence.
  • The locus coeruleus plays a significant role in dopamine-dependent memory consolidation.
  • Environmental novelty signals are detected and transmitted by specific brain circuits involving the LC-DA system.

Conclusions:

  • Dopamine signaling via D1/D5 receptors is critical for stabilizing memories in the hippocampus.
  • The locus coeruleus is a key player in novelty-driven memory enhancement.
  • Understanding these mechanisms may lead to strategies for improving memory consolidation.