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Related Experiment Videos

Plasmapheresis in familial hypercholesterolemia.

G R Thompson1, M Barbir, K Okabayashi

  • 1Department of Cardiology, Royal Postgraduate Medical School, London, United Kingdom.

Arteriosclerosis (Dallas, Tex.)
|January 1, 1989
PubMed
Summary

Plasma exchange benefits homozygous familial hypercholesterolemia. Low-density lipoprotein (LDL) apheresis shows promise as a replacement therapy, with combination treatments potentially regressing coronary lesions.

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Area of Science:

  • Cardiology
  • Biochemistry
  • Medical Technology

Background:

  • Familial hypercholesterolemia (FH) is a genetic disorder leading to high cholesterol.
  • Homozygous FH (HoFH) presents a severe form with early cardiovascular complications.
  • Plasma exchange (PE) has been a long-term treatment for HoFH.

Purpose of the Study:

  • To evaluate the long-term efficacy of plasma exchange in HoFH.
  • To explore low-density lipoprotein (LDL) apheresis as an alternative to PE.
  • To assess combination therapy for coronary lesion regression.

Main Methods:

  • Analysis of 12 years of plasma exchange data in HoFH patients.
  • Pilot studies using dextran sulfate affinity columns for LDL apheresis.
  • Investigating lovastatin combined with LDL apheresis in FH patients.

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Main Results:

  • Plasma exchange demonstrates beneficial effects on HoFH progression over 12 years.
  • LDL apheresis shows advantages over PE, suggesting potential replacement.
  • Combination therapy with lovastatin and LDL apheresis shows encouraging preliminary results for coronary lesion regression in heterozygous FH.

Conclusions:

  • Plasma exchange remains a valuable treatment for HoFH.
  • LDL apheresis is a promising alternative with potential advantages.
  • Combination therapy warrants further investigation for cardiovascular risk reduction in FH.