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Testing for Metacognitive Responding Using an Odor-based Delayed Match-to-Sample Test in Rats
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Running-based pica and taste avoidance in rats.

Sadahiko Nakajima1

  • 1Department of Psychological Science, Kwansei Gakuin University, Nishinomiya, 662-8501, Japan. nakajima@kwansei.ac.jp.

Learning & Behavior
|November 11, 2017
PubMed
Summary

Wheel running in rats causes pica behavior and taste avoidance, suggesting it induces nausea. This nausea, a key factor in taste aversion, is not alleviated by pica itself.

Area of Science:

  • Behavioral Neuroscience
  • Animal Behavior
  • Physiology

Background:

  • Pica behavior (kaolin clay intake) in rats is linked to nausea.
  • Wheel running is known to induce conditioned taste avoidance.
  • The relationship between wheel running, pica, and nausea requires further investigation.

Purpose of the Study:

  • To replicate running-induced pica behavior in rats.
  • To demonstrate concurrent running-induced pica and taste avoidance in the same animals.
  • To investigate whether pica alleviates running-induced taste avoidance and to differentiate running-induced pica from pain-induced pica.

Main Methods:

  • Replication of pica behavior in rats using activity wheels.
  • Concurrent assessment of pica and conditioned taste avoidance.
Keywords:
NauseaPicaRatTaste aversionWheel running

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  • Administration of lithium chloride (nausea-inducing) and hypertonic saline (pain-inducing) to evaluate pica generation.
  • Assessment of pica's effect on taste avoidance.

    • Main Results:

    • Wheel running reliably generated pica behavior in rats.
    • Running-induced pica and conditioned taste avoidance were demonstrated concurrently in the same animals.
    • Pica did not alleviate the running-induced taste avoidance.
    • Pica was induced by nausea-provoking lithium chloride but not by pain-provoking hypertonic saline.

    Conclusions:

    • Wheel running in rats generates pica behavior that reflects nausea.
    • The findings support the hypothesis that nausea is the underlying physiological state for running-induced pica and taste avoidance.
    • Pica behavior is a specific indicator of nausea, not pain, in this context.