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Association between metabolic syndrome and gingival inflammation in obese children

K Kâ1, M-C Rousseau1,2, S D Tran1

  • 1Division of Oral Health and Society, Faculty of Dentistry, McGill University, Montreal, QC, Canada.

International Journal of Dental Hygiene
|November 11, 2017
PubMed

Insights

Metabolic syndrome (MetS) is linked to higher tumor necrosis factor-alpha (TNF-α) in the gingival crevicular fluid (GCF) of obese boys, suggesting poorer gum health. No association was found in obese girls.

Area of Science:

  • Pediatric Endocrinology
  • Periodontology
  • Immunology

Background:

  • Previous research indicated a link between metabolic syndrome (MetS) and elevated tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF).
  • The persistence of this association specifically within obese children remained uninvestigated.

Purpose of the Study:

  • To determine the association between MetS and GCF TNF-α levels in obese children.
  • To explore potential sex differences in this relationship.

Main Methods:

  • Cross-sectional analysis of 219 obese children (aged 8-10 years) from the QUebec Adipose and Lifestyle InvesTigation in Youth (YOUTH) cohort.
  • MetS diagnosed using International Diabetes Federation criteria; GCF TNF-α measured via enzyme-linked immunosorbent assay.
  • Sex-specific linear regression analyses adjusted for confounders.

Main Results:

  • MetS was present in 10.9% of the obese children studied.
  • Obese boys with MetS exhibited 44.9% higher GCF TNF-α levels compared to those without MetS.
  • No significant association between MetS and GCF TNF-α was observed in obese girls.

Conclusions:

  • Metabolic syndrome is positively associated with GCF TNF-α concentration in obese boys.
  • Obese boys with MetS may present with a compromised gingival health status compared to their peers without MetS.
Abstract

Keywords:
childrenmetabolic syndrometumour necrosis factor-alpha

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