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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

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Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

861
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

31
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Dendritic polymers for dermal drug delivery.

Kaushalkumar Dave1, Venkata Vamsi Krishna Venuganti2

  • 1Current Affiliation: Division of Biopharmaceutics, Office of New Drug Products, Office of Pharmaceutical Quality, Center for Drug Evaluation & Research, Food & Drug Administration, Silver Spring, MD 20993, USA.

Therapeutic Delivery
|November 11, 2017
PubMed
Summary

Dendritic polymers offer a promising solution for enhancing skin drug delivery, overcoming limitations of traditional methods for nonideal molecules. These dendrimers show potential for improved topical and transdermal drug delivery with minimal irritation.

Keywords:
dendrimerdendritic polymerspermeation enhancerskin penetrationsurface chargetopicaltranscutaneoustransdermal

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Area of Science:

  • Polymer Science
  • Dermal Drug Delivery
  • Nanotechnology

Background:

  • Dermal drug delivery faces limitations with molecules possessing suboptimal physicochemical properties.
  • Conventional chemical and physical enhancement methods often cause skin irritation and reduce patient compliance.
  • Dendritic polymers have emerged as a novel class of carriers for improved dermal drug delivery.

Purpose of the Study:

  • To review the application of dendritic polymers in dermal (topical and transdermal) drug delivery.
  • To highlight the advantages of dendrimers over conventional drug delivery enhancement techniques.
  • To discuss the potential of dendrimers for delivering challenging drug molecules across the skin.

Main Methods:

  • Literature review of studies investigating dendritic polymers for dermal drug delivery.
  • Analysis of dendrimer properties relevant to skin penetration and drug loading.
  • Comparison of dendritic polymer-based delivery systems with conventional methods.

Main Results:

  • Dendritic polymers demonstrate significant potential for enhancing the dermal penetration of various drug molecules.
  • Dendrimers exhibit low skin irritation potential compared to conventional enhancers.
  • These polymers offer high drug loading capacity, facilitating efficient delivery of therapeutic agents.

Conclusions:

  • Dendritic polymers represent a versatile and effective platform for improving topical and transdermal drug delivery.
  • Their favorable properties, including minimal irritation and high drug capacity, address key limitations in conventional dermal delivery.
  • Further research into dendritic polymer-based systems is warranted to fully exploit their therapeutic potential.